Predicting Protein Secondary and Supersecondary Structure
نویسنده
چکیده
Princeton University 29.
منابع مشابه
Computational prediction of secondary and supersecondary structures.
The sequence-based prediction of the secondary and supersecondary structures enjoys strong interest and finds applications in numerous areas related to the characterization and prediction of protein structure and function. Substantial efforts in these areas over the last three decades resulted in the development of accurate predictors, which take advantage of modern machine learning models and ...
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The protein backbone is described as a smooth curved and twisted line in three-dimensional (3D) space and characterized by its curvature κ and torsion τ both expressed as a function of arc length s. It is shown that the function τ(s) is sufficient to analyze the contributions of all amino acids to the conformation of the protein backbone. The characteristic peak and trough patterns of the τ(s) ...
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The sequence patterns of 11 types of frequently occurring connecting peptides, which lead to a classification of supersecondary motifs, were studied. A database of protein supersecondary motifs was set up. An artificial neural network method, i.e. the back propagation neural network, was applied to the predictions of the supersecondary motifs from protein sequences. The prediction correctness r...
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We present a generic solvated coarse-grained protein model that can be used to characterize the driving forces behind protein folding. Each amino acid is coarse-grained with two beads, a backbone, and a side chain. Although the backbone beads are modeled as polar entities, side chains are hydrophobic, polar, or charged, thus allowing the exploration of how sequence patterning determines a prote...
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The Automated Protein Structure Analysis (APSA) method is used for the classification of supersecondary structures. Basis for the classification is the encoding of threedimensional (3D) residue conformations into a 16-letter code (3D-1D projection). It is shown that the letter code of the protein makes it possible to reconstruct its overall shape without ambiguity (1D-3D translation). According...
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تاریخ انتشار 2005